Shown on the left-hand side is Aristotle's Organon, De anima, one of the medieval manuscripts owned by the NDL. It is believed to have been transcribed in Paris in the 14th or early 15th century. Shown on the right below is the Biblia Latina, which was printed in Venice in 1475. The book design of Organon is quite similar to that of the Biblia Latina in that they both have the head titles in the margin of the page, illuminated initials, double-column layout, etc., and they are also similar in the way a blank space is left as a margin. By looking at these two items side by side, we can clearly see that incunabula took over the design of medieval manuscripts.